Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L
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A J van den Berg1, S F Horsten, J J Kettenes-van den Bosch
1Department of Pharmacognosy, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands.
FEBS Letters
|January 30, 1995
Abstract:
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.