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Does intrauterine insemination offer an advantage to cervical cap insemination in a donor insemination program?
D B Williams1, K H Moley, C Cholewa
1Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
Objective:
To compare pregnancy outcome after IUI versus cervical cap insemination in a donor insemination program.
Design:
A randomized prospective clinical trial in which patients were alternately inseminated with cryopreserved human semen using either IUI or cervical cap insemination methods.
Setting:
The donor insemination program at Washington University School of Medicine.
Patients:
Forty-two women with either isolated male factor or male factor plus corrected ovulatory dysfunction using clomiphene citrate underwent 141 cycles of donor insemination.
Main Outcome Measures:
Clinical pregnancy rates (PRs) defined as a viable intrauterine gestation > 12 weeks or delivered were compared between groups using the chi 2 test.
Results:
Clinical PRs were significantly higher in the IUI group (16.4%) compared with the cervical cap insemination group (5.9%). The spontaneous abortion rates were similar between the IUI (1.4%) and cervical cap insemination groups (4.4%).
Conclusions:
These findings suggest an advantage to IUI over cervical cap insemination in a donor insemination program.