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Related Experiment Videos

Lipid abnormalities in Turner syndrome

J L Ross1, P Feuillan, L M Long

  • 1Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107.

The Journal of Pediatrics
|February 1, 1995
PubMed
Summary

Adolescent girls with untreated Turner syndrome (TS) show elevated cholesterol levels, a cardiovascular risk factor. These lipid changes occur independently of age, body mass index, or karyotype in TS patients.

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Area of Science:

  • Endocrinology
  • Pediatric Cardiology
  • Genetics

Background:

  • Turner syndrome (TS) is linked to cardiovascular risks like insulin resistance, type II diabetes, and hypertension.
  • Early identification of cardiovascular risk factors in girls with TS is crucial for timely intervention.

Purpose of the Study:

  • To assess the lipid profiles of girls with untreated Turner syndrome.
  • To compare lipid levels in girls with TS against age-matched healthy controls.

Main Methods:

  • Lipid profiles (cholesterol, HDL cholesterol, triglycerides) were measured in 137 girls with TS (5-14 years) and 70 controls.
  • Statistical analysis adjusted for age, karyotype, and BMI z-score.

Main Results:

  • Older girls with TS (>11 years) exhibited significantly higher cholesterol levels compared to controls (190 vs. 165 mg/dl).

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  • Elevated cholesterol in TS persisted after adjusting for age, karyotype, and BMI z-score.
  • In TS subjects, cholesterol correlated with age, weight, and BMI z-score.

    • Conclusions:

    • Adolescent girls with untreated TS have significantly increased cholesterol levels.
    • These lipid abnormalities are independent of age, BMI z-score, or karyotype.
    • Cholesterol elevation in TS precedes treatment with growth hormone or estrogen therapy.