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[Prenatal eyelid development in the hl-mouse--a hairless mutant of the colored wild mouse]
1Klinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg.
Background:
A decisive condition for the clarification of malformations and degenerations is knowledge of the pre- and postnatal development. Therefore investigations were undertaken to determine the plan and lay-out of the eye-lids in an hairloss mutant of mouse.
Materials And Methods:
Biomicroscopical and histological investigations were carried out in 51 hl-mice from the 10th day of gestation unto the birth. This particular mouse is a spontaneous hairloss mutant, in which corneal degenerations also occur.
Results:
On the 11th day of gestation the ectodermal dips may be distinguished, as well as the shoe-lace-like furrows around the eye-ball, which indicate the development of the eyelids. The upper and lower lid are formed by proliferation. The fusion of the eyelids is completed around the 16th day of gestation.
Discussion:
The eyelid development starts in mice between the 11th and 14th day of gestation. The fusion is completed on day 15-17. The morphogenesis of the eyelid development will be discussed.