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Gastric acid secretion in the cynomolgus monkey
L A Dethloff1, D M Altrogge, K A Gillhouse
1Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48104.
Laboratory Animal Science
|October 1, 1994
Summary
Male and female cynomolgus monkeys show similar gastric acid secretion. Pentagastrin (PG) stimulates acid output in a dose-dependent manner, suggesting this primate is a valuable model for human gastric physiology research.
Area of Science:
- Gastroenterology
- Primate Physiology
- Pharmacology
Background:
- Gastric acid secretion is crucial for digestion and its regulation is key in human health.
- Understanding inter-species variations in gastric physiology is important for preclinical research.
Purpose of the Study:
- To investigate and compare gastric acid secretion in male and female cynomolgus monkeys.
- To determine the dose-response relationship of pentagastrin (PG) on gastric acid secretion in this primate model.
Main Methods:
- Gastric acid output was measured in male and female cynomolgus monkeys.
- Basal secretion levels were recorded.
- Intravenous administration of varying doses of pentagastrin (PG) was used to stimulate acid secretion.
Main Results:
- No significant sex-based differences were observed in basal or PG-stimulated gastric acid output.
- PG stimulated gastric acid secretion starting at 1 microgram/kg/h.
- Maximal acid secretion was achieved at PG doses of 10-100 micrograms/kg/h, indicating a plateau.
Conclusions:
- Cynomolgus monkeys exhibit comparable gastric acid secretion between sexes.
- The pentagastrin dose-response curve suggests a reliable stimulation method.
- The cynomolgus monkey serves as a relevant animal model for human gastric physiology studies.