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Related Experiment Videos

Umbilical artery velocity waveforms before and after chorionic villus sampling

R M Ibba1, G Monni, G Olla

  • 1Department of Obstetrics and Gynaecology, Università degli Studi di Cagliari, Ospedale Regionale per le Microcitemie, Sardinia, Italy.

Prenatal Diagnosis
|September 1, 1994
PubMed
Summary

Transabdominal chorionic villus sampling (TA-CVS) does not significantly alter umbilical artery pulsatility index (PI) in first-trimester pregnancies. This suggests TA-CVS does not negatively impact feto-placental circulation.

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Area of Science:

  • Maternal-Fetal Medicine
  • Diagnostic Ultrasound
  • Vascular Physiology

Background:

  • Limb and oromandibular defects have been anecdotally linked to chorionic villus sampling (CVS).
  • A vascular etiology is suspected for these defects.
  • Transabdominal CVS (TA-CVS) is an invasive first-trimester procedure.

Purpose of the Study:

  • To determine if transabdominal CVS (TA-CVS) causes significant changes in umbilical artery velocity waveforms.
  • To assess the impact of TA-CVS on the pulsatility index (PI) of the umbilical artery.

Main Methods:

  • Evaluated umbilical artery pulsatility index (PI) before and after TA-CVS.
  • Studied 175 first-trimester pregnancies (10.0-13.0 weeks' gestation).
  • Analyzed PI in uncomplicated pregnancies, those with abnormal results, and those ending in spontaneous abortion.

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Main Results:

  • No statistically significant changes in umbilical artery PI were observed relative to the TA-CVS procedure.
  • Mean PI values remained stable at 10 minutes and 1 hour post-procedure in uncomplicated pregnancies.
  • No significant PI alterations were noted in pregnancies with adverse outcomes.

Conclusions:

  • Transabdominal CVS does not appear to induce significant changes in umbilical artery pulsatility index.
  • The findings do not support a negative impact of TA-CVS on feto-placental circulation.
  • This invasive procedure is unlikely to affect fetal vascular parameters.