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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

[Candida endocarditis in non-addict patients: a disease with high mortality. A clinico-pathological study of 3 cases]

E Pastor1, G Renedo, J Fraile

  • 1División de Enfermedades Infecciosas (Departamento de Medicina), Fundación Jiménez Díaz, Universidad Autónoma de Madrid.

Revista Clinica Espanola
|November 1, 1994
PubMed

Insights

Candida endocarditis is a rare but serious fungal infection often seen in individuals with specific risk factors. Despite treatment, this condition has a very high mortality rate, highlighting diagnostic and therapeutic challenges.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Mycology

Background:

  • Candida endocarditis is a rare fungal infection linked to specific risk factors like intravenous drug use, immunosuppression, and cardiac surgery.
  • Diagnosis relies on clinical suspicion, positive blood cultures, echocardiogram findings, and evidence of the organism in vegetations or emboli.

Observation:

  • The study reports three new cases of Candida endocarditis, emphasizing the diagnostic and therapeutic complexities associated with this condition.
  • Key diagnostic indicators include valvular insufficiency murmurs, embolic events, and echocardiogram-confirmed vegetations.

Findings:

  • Candida endocarditis presents significant diagnostic challenges, requiring a high index of suspicion.
  • Despite current antifungal treatments and surgical interventions like valvular replacement, the mortality rate for Candida endocarditis remains exceedingly high, exceeding 80%.

Implications:

  • The high mortality underscores the need for improved diagnostic strategies and more effective therapeutic approaches for Candida endocarditis.
  • Further research into early detection and novel treatment modalities is crucial for improving patient outcomes in cases of invasive fungal endocarditis.

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