Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for AIDS pathogenesis

D Schenzle1

  • 1Department of Medical Biometry, University of Tübingen, Germany.

Statistics in Medicine
|October 15, 1994
PubMed
Summary
This summary is machine-generated.

Human Immunodeficiency Virus (HIV) evolves to increase its CD4+ cell reproductivity. Mathematical modeling predicts a disease progression pattern resembling observed incubation periods for Acquired Immunodeficiency Syndrome (AIDS).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct adsorption of low-density lipoprotein and lipoprotein(a) from whole blood: results of the first clinical long-term multicenter study using DALI apheresis.

Journal of clinical apheresis·2002
Same author

Analysis of a model for the pathogenesis of AIDS.

Mathematical biosciences·1997
Same author

[The question of further rabies control in Germany].

DTW. Deutsche tierarztliche Wochenschrift·1995
Same author

On the antigenic diversity threshold model for AIDS.

Mathematical biosciences·1994
Same author

Effects of human thyroxine-binding globulin and prealbumin on the reverse flow of thyroid hormones from extravascular space into the bloodstream in rabbits.

Endocrinology·1989
Same author

Antibodies to hepatitis B core antigen in blood donors screened for alanine aminotransferase level and hepatitis non-A, non-B in recipients.

Transfusion·1988
Same journal

Interpretable Bayesian Modeling for Multireader Multicase Studies: Addressing Overdispersion and Limited Sample Size in Diagnostic Enhancement Evaluation.

Statistics in medicine·2026
Same journal

Adaptive Sequential Multiple Hypotheses Testing for Concomitant Vaccine Safety Surveillance.

Statistics in medicine·2026
Same journal

Novel Distance Regression for Repeated Outcomes With Missing Data: Applications to Longitudinal and Crossover Studies of Microbiome Beta-Diversity.

Statistics in medicine·2026
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
See all related articles

Area of Science:

  • Virology
  • Immunology
  • Mathematical Biology

Background:

  • Human Immunodeficiency Virus (HIV) infection leads to a decline in CD4+ T-cells.
  • The progression of HIV to Acquired Immunodeficiency Syndrome (AIDS) has a variable incubation period.

Purpose of the Study:

  • To numerically analyze the hypothesis that HIV evolves to enhance its replication within CD4+ cells.
  • To model the dynamics of HIV infection, including initial viremia, CD4+ cell counts, and immune response.

Main Methods:

  • Development of a mathematical model to simulate HIV-1 replication and CD4+ cell dynamics.
  • Numerical analysis of model parameters and their influence on disease progression time.
  • Application of Gaussian distributions to model parameter variability.

Related Experiment Videos

Main Results:

  • The model predicts an initial drop in CD4+ cells and viremia post-infection.
  • A slow, progressive decline in CD4+ cells is observed, with HIV levels maintained low by immune response for a period.
  • The predicted incubation period distribution aligns with observed distributions for AIDS.

Conclusions:

  • HIV evolution towards increased CD4+ cell reproductivity is a plausible driver of disease progression.
  • Mathematical modeling provides insights into the factors influencing the incubation period of AIDS.
  • The study supports a mechanistic understanding of HIV pathogenesis and AIDS development.