Patterns of sleep and wakefulness in treated narcoleptic subjects

In most reported studies of treatment for narcolepsy, the efficacy of treatment has been assessed in the sleep laboratory, but not in the natural work and home settings. We therefore assessed the sleep/wake patterns of 25 subjects with narcolepsy, whose symptoms were considered under satisfactory control by the subjects and their physicians, using polygraphic recorders, and compared these with the patterns of 25 control subjects matched for age and gender. Data from one matched pair of subjects were excluded for technical reasons. There was no difference between the two groups of subjects in the total amount of sleep obtained during the 24-hour monitoring period. Narcoleptic subjects had shorter nocturnal sleep latencies and more disrupted nocturnal sleep than control subjects. Despite taking their usual medications, narcoleptic subjects averaged 44 minutes of daytime sleep compared to 4.8 minutes for controls. There was wide variation in the amount of daytime sleep among narcoleptics: 10 subjects did not sleep during the day, whereas the other 14 averaged 2.7 naps per day for an average of 76.2 minutes of daytime sleep. These findings indicate that daytime sleep episodes were common in narcoleptic patients who considered their treatment satisfactory. Wide variations in the amount of daytime sleep may reflect differences in disease severity, responsiveness to medications or willingness to tolerate daytime sleep episodes.