Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Progressive multifocal leukoencephalopathy]

N J Hansen1, C Madsen, E Stenager

  • 1Neuromedicinsk afdeling N, Odense Universitetshospital.

Ugeskrift for Laeger
|January 16, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution of elevation and residential proximity to the coast in explaining geographic variations in hip fracture incidence. A Norwegian Epidemiologic Osteoporosis Studies (NOREPOS) study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Time matters: Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains.

Multiple sclerosis (Houndmills, Basingstoke, England)·2020
Same author

Response to letter regarding Tobacco smoking.

Journal of internal medicine·2020
Same author

The association between heart diseases and suicide: a nationwide cohort study.

Journal of internal medicine·2020
Same author

Variation in expenditure for common, high cost surgical procedures in a working age population: implications for reimbursement reform.

BMC health services research·2019
Same author

Hospital ethics reflection groups: a learning and development resource for clinical practice.

BMC medical ethics·2019
Same journal

[Mosaicism as a cause of Cowden syndrome].

Ugeskrift for laeger·2026
Same journal

[Thyrotoxic crisis with cardiogenic shock].

Ugeskrift for laeger·2026
Same journal

[Mindfulness-based cognitive therapy in the treatment of depression].

Ugeskrift for laeger·2026
Same journal

[Fitness].

Ugeskrift for laeger·2026
Same journal

[Risk of developing cataract related to fluoroscopy].

Ugeskrift for laeger·2026
Same journal

[Obturator hernia with small bowel ileus presenting as hip pain in an elderly woman].

Ugeskrift for laeger·2026
See all related articles

Progressive multifocal leukoencephalopathy (PML) is a rare brain disease caused by JC virus (JCV). While often fatal, some treatments like cytosine arabinoside show promise, especially with immunomodulation in HIV-infected patients.

Area of Science:

  • Neurology
  • Virology
  • Immunology

Context:

  • Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system.
  • It is caused by the neurotropic JC virus (JCV).
  • PML predominantly affects immunocompromised individuals with impaired cellular immunity.

Purpose:

  • To review the current understanding of Progressive multifocal leukoencephalopathy (PML).
  • To discuss the increasing incidence of PML in relation to HIV infection and immunosuppressive therapies.
  • To explore potential therapeutic strategies and diagnostic approaches.

Summary:

  • PML primarily affects the cerebral hemispheres, cerebellum, and brain stem.
  • Increased use of immunosuppressive therapy, organ transplantation, and the rise of HIV/AIDS have led to a higher incidence of PML.

Related Experiment Videos

  • While typically rapidly progressive and fatal, some cases show prolonged survival or remission with treatments like cytosine arabinoside and AZT/zidovudine in HIV-infected patients.

    • Impact:

    • The review highlights the need for extensive immunological investigation upon suspicion of PML.
    • Increased understanding of PML pathogenesis, particularly in HIV-infected individuals, may lead to effective therapeutic strategies.
    • Brain biopsy remains the definitive diagnostic test for PML.