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Chemotherapy and delivery systems: haemoparasites
1International Laboratory for Research on Animal Diseases (ILRAD), Nairobi, Kenya.
Veterinary Parasitology
|August 1, 1994
Summary
Drug resistance is a growing concern for trypanosomosis treatment in animals, unlike tick-borne diseases. This review examines resistance mechanisms and alternative drug preparations to improve chemotherapy effectiveness.
Area of Science:
- Veterinary Medicine
- Parasitology
- Pharmacology
Background:
- Chemotherapy for animal haemoparasitic diseases relies on a limited drug class.
- Trypanosomosis chemotherapy faces increasing drug resistance challenges.
- Tick-borne diseases (theileriosis, babesiosis, anaplasmosis, cowdriosis) show less drug resistance.
Purpose of the Study:
- To review current drugs for trypanosomosis and tick-borne diseases.
- To analyze the development and mechanisms of drug resistance in trypanosomes.
- To discuss reasons for lack of resistance in tick-borne disease treatments and explore alternative trypanocide preparations.
Main Methods:
- Literature review of drug resistance identification and quantification in trypanosomes.
- Analysis of reports on trypanocide resistance and cross-resistance.
- Evaluation of alternative drug formulations to reduce local toxicity.
Main Results:
- Drug resistance is a significant and increasing problem for trypanosomosis.
- Limited reports of resistance exist for drugs used against tick-borne haemoparasites.
- Alternative trypanocide preparations aim to mitigate injection site toxicity.
Conclusions:
- Integrated control strategies combining chemotherapy and vector management are crucial for trypanosomosis, especially with rising drug resistance.
- Further research into the lack of resistance in tick-borne disease treatments may offer insights.
- Development of less toxic and more effective chemotherapeutic agents is needed.