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Related Experiment Videos

Anthelmintic resistance

R Prichard1

  • 1Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Que., Canada.

Veterinary Parasitology
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Anthelmintic resistance is a growing problem in livestock parasites. New in vitro diagnostic tools and molecular insights are improving the detection and understanding of resistance mechanisms.

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Area of Science:

  • Veterinary Parasitology
  • Molecular Biology
  • Biochemistry

Background:

  • Anthelmintic resistance is prevalent in sheep, goat, and horse nematodes, and emerging in cattle and pigs.
  • Specific resistances include benzimidazole, levamisole/morantel, ivermectin, and closantel.

Purpose of the Study:

  • To review the current state of anthelmintic resistance in livestock.
  • To discuss methods for detecting anthelmintic resistance.
  • To explore the biochemical and molecular underpinnings of resistance.

Main Methods:

  • Review of existing literature on anthelmintic resistance.
  • Discussion of traditional methods like worm/egg count reduction.
  • Highlighting development of in vitro assays (egg hatch, larval development).

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Main Results:

  • Widespread anthelmintic resistance necessitates improved detection methods.
  • In vitro assays offer faster, more sensitive alternatives.
  • Molecular mechanisms of resistance are being elucidated (e.g., beta-tubulin for benzimidazoles, cholinergic receptors for levamisole/morantel, glutamate receptors for ivermectin).

Conclusions:

  • Understanding resistance mechanisms aids in developing sensitive diagnostic tools, like DNA probes.
  • Continued research into molecular genetics will improve detection and management of anthelmintic resistance.