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[Insulin resistance and cardiovascular complications]
1II. Medizinische Abteilung, Zentralkrankenhaus Bremen-Nord, Bundesrepublik Deutschland.
Wiener Klinische Wochenschrift
|January 1, 1994
Summary
Insulin resistance, a genetically determined condition, is linked to cardiovascular disease risk factors like obesity and hypertension. Early diagnosis in the prediabetic stage is crucial for managing these risks.
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Medicine
- Epidemiology
Context:
- Insulin resistance and hyperinsulinemia are associated with dyslipidemia, hypertension, and obesity.
- The insulin-resistance syndrome presents a cluster of cardiovascular risk factors.
- Non-insulin-dependent diabetes mellitus (NIDDM) exhibits a 3-4 times higher incidence of cardiovascular disease.
Purpose:
- To explore the link between insulin resistance and cardiovascular disease.
- To highlight the early diagnostic potential of insulin resistance in the prediabetic stage.
- To elucidate the pathogenetic mechanisms of insulin resistance as a cardiovascular risk factor.
Summary:
- Epidemiologic and clinical studies demonstrate a strong association between insulin resistance, hyperinsulinemia, and cardiovascular risk factors.
- Insulin resistance is genetically determined and can be diagnosed in the prediabetic stage, preceding clinical diabetes.
- Pathogenesis involves direct atherogenic effects of insulin on vessel walls and indirect effects on obesity, blood pressure, lipids, and hemostasis.
Impact:
- Understanding the early markers of cardiovascular disease risk in insulin resistance.
- Facilitating early intervention strategies for individuals at risk of NIDDM and cardiovascular complications.
- Providing insights into the direct and indirect atherogenic mechanisms of hyperinsulinemia.