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Basic study on hepatic resection under partial perfusion cooling

I Hamamoto1, M A Hossain, S Okada

  • 1First Department of Surgery, Kagawa Medical School, Japan.

World Journal of Surgery
|November 1, 1994
PubMed
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A novel L-histidine perfusion solution (KM solution) significantly improved liver quality and viability after partial hepatectomy and cooling. This new solution enhanced blood flow recovery and 1-week survival rates in rats undergoing liver surgery.

Area of Science:

  • Hepatobiliary Surgery
  • Organ Preservation
  • Transplantation Medicine

Background:

  • Partial hepatectomy requires liver preservation techniques.
  • Hypothermic preservation (HPC) is used to maintain liver quality during surgery.
  • Improving organ quality after reperfusion is critical for patient outcomes.

Purpose of the Study:

  • To develop and evaluate a new perfusion solution for hypothermic liver preservation (HPC).
  • To assess the efficacy of a 100 mM L-histidine (KM) solution in preserving liver quality after partial hepatectomy and cooling.

Main Methods:

  • Lewis rat livers were perfused with either lactated Ringer's (LR) solution or the KM solution at 20°C.
  • Livers were reperfused with rat blood at 37°C, monitoring blood flow.

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  • Bile production, lactate dehydrogenase (LDH) secretion, and tissue adenosine triphosphate (ATP) levels were measured.
  • In situ liver perfusion and partial hepatectomy were performed, followed by 1-week survival monitoring.

    • Main Results:

    • KM solution significantly improved portal and peripheral tissue blood flow recovery post-reperfusion compared to LR solution.
    • Liver viability, assessed by bile production, ATP levels, and LDH release, was better preserved with KM solution.
    • One-week survival rates were 25% for LR group and 100% for KM group (p < 0.05) after partial hepatectomy.

    Conclusions:

    • The KM solution is effective in preserving liver quality during hypothermic preservation and partial hepatectomy.
    • KM solution enhances organ recovery and improves survival outcomes following liver surgery.
    • L-histidine-based perfusion solutions show promise for improving liver preservation in surgical settings.