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Early stage gastric lymphoma: is operation essential?
Y Tanaka1, T Takao, H Watanabe
1Department of Surgery, Osaka Prefectural Hospital, Japan.
World Journal of Surgery
|November 1, 1994
Summary
Primary chemotherapy effectively eliminated malignant cells in early-stage gastric lymphoma patients. Surgery may not be essential for treating stage IE/IIE gastric lymphoma.
Area of Science:
- Oncology
- Gastroenterology
- Hematology
Background:
- Gastric lymphoma is a rare malignancy.
- Early-stage disease often requires multimodal treatment.
- The role of neoadjuvant chemotherapy is under investigation.
Purpose of the Study:
- To evaluate the efficacy of primary chemotherapy in early-stage gastric lymphoma.
- To determine if chemotherapy alone can achieve remission before surgery.
Main Methods:
- Five patients with stage IE/IIE primary gastric lymphoma received two cycles of VEPA chemotherapy.
- Diagnosis was confirmed via endoscopic biopsy.
- Surgical resection (gastrectomy, lymph node dissection, splenectomy) was performed post-chemotherapy.
Main Results:
- All five patients achieved complete remission with no residual lymphoma cells found in surgical specimens.
- Four out of five patients showed regional lymph node swelling.
- No recurrence was observed in patients during a 12-40 month follow-up period.
Conclusions:
- Primary chemotherapy demonstrated significant efficacy in treating early-stage gastric lymphoma.
- Neoadjuvant chemotherapy may render surgery unnecessary for select patients.
- Further research is warranted to confirm these findings and refine treatment protocols.