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Updated: Aug 25, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Cardioversion in atrial fibrillation]
1Abteilung für Kardiologie, Universitätskrankenhaus Eppendorf, Hamburg.
Insights
Atrial fibrillation management requires careful consideration. External electrical cardioversion is preferred for restoring sinus rhythm over antiarrhythmic drugs due to potential mortality risks, reserving internal cardioversion for refractory cases.
Area of Science:
- Cardiology
- Electrophysiology
- Internal Medicine
Context:
- Atrial fibrillation presents with palpitations, hemodynamic compromise, and thromboembolic risks.
- Antiarrhythmic drug therapy for maintaining sinus rhythm can increase mortality.
- Current treatment strategies necessitate a nuanced approach to rhythm control.
Purpose:
- To evaluate the optimal strategy for achieving and maintaining sinus rhythm in patients with atrial fibrillation.
- To compare the efficacy and safety of different cardioversion methods and pharmacologic interventions.
Summary:
- External electrical cardioversion is recommended for achieving sinus rhythm in selected atrial fibrillation patients due to potential mortality benefits over drug therapy.
- Internal electrical cardioversion should be reserved for patients unresponsive to external methods.
- Implantable automatic cardioversion devices are still under investigation.
Impact:
- Provides evidence-based guidance for clinicians managing atrial fibrillation rhythm control.
- Highlights the risks associated with antiarrhythmic drugs, emphasizing procedural interventions.
- Informs future research directions for novel atrial fibrillation therapies and devices.
Abstract:
Atrial fibrillation is often not only associated with palpitations, but also with hemodynamic detoriation and high incidence of thromboembolic complications. However, since the establishment or maintenance of a sinus rhythm with antiarrhythmic drugs may also lead to an increased mortality, sinus rhythm should only be achieved by external electrical cardioversion and should be limited to those patients who have been shown to, or may be expected to markedly improved by this intervention. Internal electrical cardioversion should be restricted to those patients who fail external cardioversion. Implantable devices to automatically cardiovert atrial fibrillation are still under clinical investigation and will require further evaluation.
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