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Idiopathic intracranial hypertension. Lack of histologic evidence for cerebral edema
M Wall1, J D Dollar, A A Sadun
1Department of Neurology, University of Iowa, College of Medicine, Iowa City.
Objective:
To study brain histologic features in two cases of idiopathic intracranial hypertension (pseudotumor cerebri) at autopsy.
Design:
Formaldehyde solution-fixed sections of cerebral white matter in two cases and structures of the sensory visual system in one case were analyzed.
Setting:
University medical center.
Patients:
Two patients with idiopathic intracranial hypertension who died unexpectedly.
Main Outcome Measure:
Histologic study of cerebral white matter in the two patients.
Results:
We did not find histologic evidence of any type of cerebral edema in our patients. Review of a portion of the material from a previous report is also consistent with this conclusion.
Conclusion:
If patients with idiopathic intracranial hypertension have histologically apparent cerebral edema, it is not a consistent finding.