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Related Experiment Videos

Pain assessment after intramuscular injection

C Surber1, E Lüdin, A Flückiger

  • 1F. Hoffmann-La Roche AG, Basel, Switzerland.

Arzneimittel-Forschung
|December 1, 1994
PubMed
Summary

Injectable drug preparations cause varying levels of injection pain, impacting patient comfort. A validated pain questionnaire effectively measured these differences, aiding in the selection of less painful formulations.

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Area of Science:

  • Pharmacology
  • Clinical Practice
  • Pain Management

Background:

  • Local tolerance of injectable drugs, influenced by factors like pH and osmotic pressure, is well-studied.
  • However, post-injection pain, a common clinical issue, has received limited research attention.

Purpose of the Study:

  • To investigate and quantify the pain experienced after deep ventrogluteal injections of different cotrimoxazole and multivitamin preparations.
  • To evaluate the utility of a pain questionnaire in assessing subjective pain symptoms associated with injectable drug administration.

Main Methods:

  • A double-blind, cross-over study involving healthy volunteers.
  • Participants received cotrimoxazole or multivitamin preparations and placebo, reporting pain up to 24 hours post-injection.
  • Pain was assessed using a questionnaire including pain localization, visual analog scale (VAS) for intensity, and pain rating index (PRI) for verbal description.

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Main Results:

  • Significant differences in induced pain (VAS, PRI) were observed among the tested preparations (p < 1%).
  • Pairwise comparisons revealed significant variations in pain levels between specific formulations (p < 5%).
  • A high correlation was found between VAS and PRI pain parameters (Spearman's rank correlation).

Conclusions:

  • Injectable preparations significantly differ in their capacity to induce post-injection pain.
  • The utilized pain questionnaire is a valuable and sensitive tool for evaluating subjective pain symptoms following injections.
  • Findings support the use of this questionnaire in clinical practice to identify and select less painful drug formulations.