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Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA
D Pfaffinger1, J Mc Lean, A M Scanu
1Department of Medicine, University of Chicago, IL 60637.
Biochimica Et Biophysica Acta
|November 25, 1993
Abstract:
We have been able to amplify the lysine binding pocket region of human apo(a) kringle type 5 starting from the DNA isolated from peripheral blood lymphocytes. This development now permits the identification of Lp(a) mutants that by lacking their ability to bind to lysine/fibrin would have a lesser thrombogenic potential.