Related Experiment Video
Updated: Aug 9, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
Published on: June 26, 2018
The first spinal anesthesia. Who deserves the laurels?
1Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York.
Corning's early attempt at spinal anesthesia was likely an extradural block, not a true spinal anesthetic. August Bier is credited with the first authentic spinal anesthesia, using cocaine.
Area of Science:
- Anesthesiology
- Neurology
- Medical History
Background:
- Investigating the historical debate surrounding James Leonard Corning's 1885 cocaine injection.
- Comparing Corning's procedure with early authentic spinal anesthesia techniques by Bier and Tuffier.
Discussion:
- Corning's injection details, including dose, onset, and sensory level, suggest an extradural rather than a spinal block.
- Corning's proposed mechanism of action differed significantly from established understanding of spinal anesthesia.
Key Insights:
- Corning's cocaine injection did not involve cerebrospinal fluid, unlike authentic spinal anesthesia.
- Corning used a higher dose of cocaine with slower onset and lower sensory level compared to Bier and Tuffier.
- Corning theorized venous absorption for cocaine's effect, contrasting with direct spinal cord action.
Outlook:
- Re-evaluating historical contributions to spinal anesthesia.
- Clarifying the distinction between extradural and spinal anesthesia in early practices.
- Highlighting August Bier's definitive contribution to spinal anesthesia.
More Related Videos
Related Concept Videos
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Stages of General Anesthesia

