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Related Experiment Videos

First experience with a new echographic contrast agent

G Cennamo1, N Rosa, G F Vallone

  • 1Istituto di Oftalmologia, Università Federico II Napoli, Italy.

The British Journal of Ophthalmology
|November 1, 1994
PubMed
Summary
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Ultrasound contrast agents enhance blood flow signals. A galactose microparticle agent (SH U 508 A) showed safety in animals and improved Doppler signals in 10 patients with ocular tumors.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Oncology

Background:

  • Ultrasound contrast agents improve blood flow signal detection.
  • SH U 508 A, a galactose microparticle agent, is safe and effective in animal studies.
  • Ocular tumors present diagnostic challenges in vascularity assessment.

Purpose of the Study:

  • To evaluate the efficacy of SH U 508 A in enhancing Doppler signals in patients with malignant orbital and ocular tumors.
  • To assess the potential of this contrast agent in evaluating tumor vascularity and radiotherapy response.

Main Methods:

  • Ten patients with malignant orbital and ocular tumors were included.
  • Echo color Doppler imaging was performed before and after intravenous injection of SH U 508 A.
  • Signal enhancement in tumor lesions was quantitatively and qualitatively assessed.

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Main Results:

  • SH U 508 A significantly enhanced Doppler signals in ocular tumor lesions.
  • The degree of enhancement varied among different tumor types.
  • The agent facilitated visualization of tumor vascularity.

Conclusions:

  • SH U 508 A is a valuable echographic contrast agent for evaluating vascular lesions in ophthalmic oncology.
  • It aids in assessing tumor vascularity and potentially monitoring radiotherapy effectiveness.
  • This agent may expand the diagnostic applications of echography in ophthalmology.