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Physiological and pathological changes in tissue monoamine oxidase activity

M B Youdim, M Holzbauer

    Journal of Neural Transmission
    |January 1, 1976
    PubMed
    Summary
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    Monoamine oxidase (MAO) malfunction may affect brain biogenic amine breakdown and mental health, but conclusive evidence is lacking. This review examines normal MAO enzyme functions and their relation to mental abnormalities.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Psychiatry

    Background:

    • The enzyme monoamine oxidase (MAO) is crucial for breaking down biogenic amines in the central nervous system.
    • Dysregulation of biogenic amine metabolism is hypothesized to contribute to mental abnormalities.
    • Understanding MAO's role is key to exploring the biochemical basis of psychiatric disorders.

    Purpose of the Study:

    • To investigate the potential link between monoamine oxidase (MAO) malfunction and mental abnormalities.
    • To review existing data on the normal physiological functions of MAO.
    • To assess the current evidence supporting MAO's involvement in psychiatric conditions.

    Main Methods:

    • Literature review of studies on monoamine oxidase (MAO) function and its relation to central nervous system biogenic amine catabolism.

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  • Analysis of data concerning MAO's multiple forms, hormonal regulation, and developmental expression.
  • Examination of evidence linking MAO activity to mental abnormalities.

    • Main Results:

    • No conclusive evidence was found to directly link monoamine oxidase (MAO) malfunction to specific mental abnormalities.
    • Data reviewed highlighted the complex nature of MAO, including its existence in multiple forms.
    • Information on hormonal control and developmental aspects of MAO activity was presented.

    Conclusions:

    • While a theoretical link exists, current evidence does not substantiate a direct causal relationship between MAO malfunction and mental abnormalities.
    • Further research is needed to fully elucidate the role of MAO in the central nervous system and its potential implications for mental health.
    • The review underscores the importance of understanding MAO's normal functions for future investigations.