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Genetic and epigenetic control in neural crest development

N M Le Douarin1, E Dupin, C Ziller

  • 1Institut d'Embryologie Cellulaire et Moléculaire, CNRS, Nogent-sur-Marne, France.

Current Opinion in Genetics & Development
|October 1, 1994
PubMed
Summary

The vertebrate neural crest, crucial for embryonic development, involves cell migration regulated by the Slug gene. Neural crest cells show pluripotency and stem cell potential, influenced by genetic and environmental factors.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Embryology

Background:

  • The neural crest is a transient embryonic structure in vertebrates.
  • Neural crest cells undergo an epithelial-to-mesenchymal transition to become migratory.
  • The 'Slug' gene, a 'Snail' family transcription factor, controls this migratory phase.

Purpose of the Study:

  • To explore the developmental potential and regulation of neural crest cells.
  • To understand the role of intrinsic and extrinsic factors in neural crest cell diversification.
  • To investigate the genetic control of neural crest development, particularly in head formation.

Main Methods:

  • Analysis of gene function, including the 'Slug' gene.
  • Investigation of neurotrophin gene disruption effects.

Related Experiment Videos

  • Examination of vertebrate Hox gene involvement in neural crest development.

    • Main Results:

    • Neural crest cells exhibit pluripotency and totipotent stem cell populations during migration.
    • Disruption of neurotrophin genes leads to deficiencies in neural crest derivatives.
    • Vertebrate Hox genes are essential for neural crest development, especially in the rhombencephalic region.

    Conclusions:

    • Neural crest cell fate is determined by a combination of intrinsic properties and extrinsic influences.
    • The neural crest plays a vital role in vertebrate head and hypobranchial development.
    • Genetic factors, such as 'Slug' and Hox genes, are critical regulators of neural crest ontogeny.