Malignant eccrine neoplasms of the foot
M Pontone1, G K Potter, S J Berlin
1Maryland Podiatric Residency Program, Bon Secours Hospital, Baltimore, Maryland.
Summary
Eccrine cancers are rare foot tumors, often affecting middle-aged men. While potentially serious, these pedal lesions showed no recurrence in a small podiatric study group.
Area of Science:
- Dermatology
- Oncology
- Podiatric Medicine
Background:
- Eccrine cancers are uncommon malignant neoplasms.
- These cancers can be recurrent, metastatic, and fatal.
- Primary foot lesions are rare presentations of eccrine cancers.
Purpose of the Study:
- To review and analyze documented cases of eccrine cancers on the foot.
- To characterize the epidemiology, clinical presentation, and outcomes of pedal eccrine carcinomas.
Main Methods:
- A comprehensive literature search was conducted for eccrine cancers of the foot.
- Data from a podiatric facility's skin biopsies over 15 years were analyzed.
- Demographic, clinical, and histopathological features were extracted and synthesized.
Main Results:
- 46 cases from literature and 8 from a podiatric facility were analyzed (total 54 cases).
- Males predominated (57.1%) in the combined cohort, with an average age at diagnosis of approximately 55.
- Most lesions occurred on the sole, with common types including porocarcinoma and adenocarcinoma; no distinguishing clinical features were noted compared to other pedal tumors.
Conclusions:
- Eccrine cancers of the foot are rare, predominantly affecting middle-aged men.
- While potentially aggressive, the cases reviewed showed no recurrence or metastasis within the follow-up period.
- Clinical presentation does not reliably differentiate eccrine cancers from other foot tumors, necessitating biopsy for diagnosis.
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