Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sex determination

J R Hawkins1

  • 1Department of Genetics, Cambridge University, Cambridge UK.

Human Molecular Genetics
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

The discovery of the SRY gene for testis determination was revolutionary. Unexpected findings, including SRY mutations and unique transcripts, continue to advance human sex determination research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International reference reagents to standardise blood group genotyping: evaluation of candidate preparations in an international collaborative study.

Vox sanguinis·2012
Same author

Genetic reference materials and their application to haematology.

Biologicals : journal of the International Association of Biological Standardization·2010
Same author

In vitro effects of ethanol, acetaldehyde and fatty acid ethyl esters on human erythrocytes.

Alcohol and alcoholism (Oxford, Oxfordshire)·2002
Same author

Developmental aspects of androgen action.

Molecular and cellular endocrinology·2001
Same author

Clinical and molecular evidence for the role of androgens and WT1 in testis descent.

Molecular and cellular endocrinology·2001
Same author

Evidence that longer androgen receptor polyglutamine repeats are a causal factor for genital abnormalities.

The Journal of clinical endocrinology and metabolism·2001
Same journal

Utrophin requires α-Syntrophin to maintain neuromuscular junction integrity in mdx mice.

Human molecular genetics·2026
Same journal

A novel gene ACTRT3 mutations induce sperm malformations and fertilization failure via Acrosomal ultrastructural defects.

Human molecular genetics·2026
Same journal

Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.

Human molecular genetics·2026
Same journal

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026
Same journal

Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.

Human molecular genetics·2026
Same journal

Retraction: Aqua-soluble DDQ reduces the levels of Dr1 and Ab and inhibits abnormal interactions between Ab and Dr1 and protects Alzheimer's disease neurons from Ab- and Dr1-induced mitochondrial and synaptic toxicities.

Human molecular genetics·2026
See all related articles

Area of Science:

  • Genetics
  • Developmental Biology
  • Human Molecular Biology

Background:

  • The identification of the SRY gene marked a significant advancement in understanding human sex determination.
  • Despite initial high expectations, the isolation of additional sex-determining genes has proven challenging.
  • The SRY gene remains a focal point of research due to its complex biology.

Purpose of the Study:

  • To explore the ongoing research and discoveries surrounding the SRY gene.
  • To highlight the unpredictable biological aspects of SRY that have emerged.
  • To underscore the continued importance of SRY in the field of sex determination.

Main Methods:

  • Review of existing literature on SRY gene function and mutations.
  • Analysis of reported cases of sex reversal associated with SRY.

Related Experiment Videos

  • Investigation of studies on SRY sequence evolution and transcript variations.

    • Main Results:

    • Sex-reversing SRY mutations exhibit variable penetrance but full expressivity.
    • SRY gene sequences show rapid evolutionary changes across species.
    • Novel findings include the existence of circular SRY transcripts.

    Conclusions:

    • The biology of SRY is more complex and unpredictable than initially anticipated.
    • SRY mutations and variations continue to provide critical insights into sex determination mechanisms.
    • Further research into SRY's unique features is essential for a comprehensive understanding of human development.