Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemopoietic stem cells: sources and applications

D S Hong1, H J Deeg

  • 1Program in Transplantation Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

Medical Oncology (Northwood, London, England)
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors.

ESMO open·2025
Same author

Efficacy and safety of larotrectinib as first-line treatment for patients with TRK fusion cancer.

ESMO open·2025
Same author

A phase I study of TAK-659 and paclitaxel in patients with taxane-refractory advanced solid tumors.

ESMO open·2024
Same author

A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067.

Nature·2023
Same author

PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers.

ESMO open·2021
Same author

Safety and activity of vandetanib in combination with everolimus in patients with advanced solid tumors: a phase I study.

ESMO open·2021

Hematopoietic stem cells from bone marrow, peripheral blood, and umbilical cord blood are used for transplantation. Umbilical cord blood shows promise for gene transfer and adult transplants due to its accessibility and stem cell richness.

Area of Science:

  • Hematology and Transplantation Medicine

Background:

  • Bone marrow has been the traditional source for hematopoietic stem cells for transplantation.
  • Mobilized peripheral blood stem cells offer rapid hematopoietic reconstitution.
  • Umbilical cord blood is an accessible and increasingly utilized stem cell source, particularly for pediatric transplants.

Purpose of the Study:

  • To review current and emerging sources of hematopoietic stem cells for transplantation.
  • To compare the advantages and disadvantages of different stem cell sources.
  • To highlight the potential of umbilical cord blood stem cells.

Main Methods:

  • Review of existing literature on stem cell sources and transplantation.
  • Analysis of clinical applications of bone marrow, peripheral blood, and cord blood stem cells.

Related Experiment Videos

  • Discussion of technological advancements in stem cell expansion and gene transfer.

    • Main Results:

    • Mobilized peripheral blood stem cells provide faster engraftment than traditional bone marrow transplants.
    • Umbilical cord blood stem cells are effective in pediatric transplants, even across histocompatibility barriers.
    • Umbilical cord blood stem cells may be advantageous for in vitro expansion and gene transfer applications.

    Conclusions:

    • Umbilical cord blood represents a promising alternative stem cell source with potential for adult transplantation and gene therapy.
    • Advancements in technology are expanding the utility of cord blood stem cells.
    • The choice of stem cell source depends on clinical application and patient characteristics.