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Percutaneous cryosurgery for renal tumours
M Uchida1, Y Imaide, K Sugimoto
1Department of Urology, Kyoto Prefectural University of Medicine, Japan.
British Journal of Urology
|February 1, 1995
Summary
Percutaneous cryosurgery effectively treated hypervascular renal tumors in two patients, causing tumor necrosis and shrinkage. Temporary improvements suggest potential minimally invasive applications for advanced renal carcinoma.
Area of Science:
- Nephrology
- Surgical Oncology
- Cryobiology
Background:
- Renal tumors present treatment challenges, necessitating minimally invasive options.
- Percutaneous cryosurgery offers a potential alternative for managing renal malignancies.
Observation:
- A novel liquid nitrogen cryoprobe was developed and tested.
- Renal cancer cells require temperatures below -20°C for necrosis.
- Pre-treatment embolization of the renal artery may be beneficial for hypervascular tumors.
Findings:
- Percutaneous cryosurgery successfully induced necrosis and shrinkage of renal tumors in two advanced renal carcinoma patients.
- Post-operative Karnofsky performance scale showed initial improvement, followed by general deterioration.
- Patient outcomes included survival of 10 and 5 months post-procedure.
Implications:
- Percutaneous cryosurgery demonstrates feasibility for advanced renal carcinoma.
- Cryo-immunological activity may contribute to temporary clinical improvements.
- Further research is warranted to establish its role in minimally invasive renal tumor treatment.