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Persistent polyuria after posterior urethral valves

M D Dinneen¹, P G Duffy, T M Barratt

¹Department of Urology, Hospitals for Sick Children, London, UK.

British Journal of Urology

|February 1, 1995

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Boys with posterior urethral valves often experience persistent polyuria after treatment. This can impact urinary continence and lead to ongoing kidney impairment, highlighting the need for continued monitoring.

Area of Science:

Pediatric Nephrology
Urology
Renal Physiology

Background:

Posterior urethral valves (PUV) are a common congenital anomaly in male infants.
Valve ablation is the primary treatment, but long-term renal function and urinary handling require evaluation.

Purpose of the Study:

To evaluate urinary concentrating ability, urine production, and glomerular filtration rates (GFR) in boys with a history of treated PUV.
To identify potential correlations between these parameters and long-term renal health.

Main Methods:

Assessed urinary concentrating capacity using overnight urine osmolality and stimulated maximum concentrating ability with desamino-cys-1-8-D-arginine vasopressin.
Calculated 24-hour urine volumes from frequency/volume charts.
Estimated glomerular filtration rate (GFR) via 51Cr-ethylenediamine tetra-acetic acid plasma clearance.

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Main Results:

59% of boys exhibited impaired urinary concentrating capacity (< 800 mOsm/kg).
Mean 24-hour urine volume was 1025 mL; mean GFR was 81 mL/min/1.73 m2SA.
Significant correlations were found between GFR, maximum urine concentration, and 24-hour urine volume.

Conclusions:

Persistent polyuria is a common sequela following posterior urethral valve ablation.
Impaired concentrating ability and polyuria have significant implications for urinary continence and ongoing renal impairment in affected boys.