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Persistence of mumps viral antigens in mouse brain
The Japanese Journal of Experimental Medicine
|June 1, 1976
Abstract:
Newborn mice were infected intracerebrally with a fresh isolate of mumps virus. Although infectious virus could not be recovered after the acute infection, direct immunofluorescence demonstrated the persistence of mumps antigens for up to 100 days after the initial infection.
Insights
Mumps virus infection in newborn mice showed no infectious virus after acute illness. However, mumps antigens persisted for up to 100 days, indicating long-term viral presence.
Area of Science:
- Virology
- Immunology
- Neuroscience
Background:
- Mumps virus can cause serious neurological complications.
- Understanding the persistence of mumps virus in the central nervous system is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the persistence of mumps virus antigens in the brains of newborn mice after intracerebral infection.
Main Methods:
- Newborn mice were infected intracerebrally with a mumps virus isolate.
- Virus recovery attempts were made after the acute infection phase.
- Direct immunofluorescence was used to detect viral antigens.
Main Results:
- Infectious mumps virus was not recovered after the acute infection.
- Mumps virus antigens were detected in the brain for up to 100 days post-infection.
Conclusions:
- Mumps virus can establish a persistent, non-infectious presence in the brain.
- Viral antigens may persist long after infectious virus is cleared, potentially contributing to chronic inflammation or neurological damage.