Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular hyperfiltration in young Polynesians with type 2 diabetes

R Bruce1, M Rutland, T Cundy

  • 1Department of Medicine, Auckland Hospital, New Zealand.

Diabetes Research and Clinical Practice
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of innovative simulation teaching for advanced general practice clinical pharmacists.

International journal of clinical pharmacy·2021
Same author

Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test.

Scientific reports·2021
Same author

Treat-to-target-mainstream or marketing?

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Assessing the outcomes of pregnancies of women with diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Outbreak of Escherichia coli O157 Phage Type 32 linked to the consumption of venison products.

Epidemiology and infection·2018
Same author

Fœtus with Exomphalos and Sacral Hygroma.

Transactions. Edinburgh Obstetrical Society·2018

Hyperfiltration, an elevated glomerular filtration rate, is common in young Polynesians with newly diagnosed type 2 diabetes. This early kidney function abnormality may predict future diabetic nephropathy.

Area of Science:

  • Nephrology
  • Diabetology
  • Endocrinology

Background:

  • Diabetic nephropathy is a major complication of type 2 diabetes.
  • Hyperfiltration is a potential early indicator of diabetic nephropathy.
  • Prevalence of hyperfiltration varies across different populations.

Purpose of the Study:

  • To investigate the prevalence of hyperfiltration in young Polynesians with type 2 diabetes.
  • To assess early renal function changes in this specific population.

Main Methods:

  • Measured glomerular filtration rate (GFR) using 51Cr EDTA clearance.
  • Studied 15 young Polynesian type 2 diabetes patients (1-30 months post-diagnosis) and 15 controls.
  • Adjusted GFR for body size (per 1.73 m2).

Related Experiment Videos

Main Results:

  • Diabetic subjects showed a 57% higher mean GFR (216 ml/min) than controls (137.5 ml/min).
  • Even after adjusting for obesity, diabetic subjects had significantly higher GFR (165.6 vs. 119.6 ml/min per 1.73 m2).
  • 73% of diabetic subjects exhibited hyperfiltration (> 140 ml/min per 1.73 m2) and increased albumin excretion.

Conclusions:

  • Hyperfiltration is prevalent in young Polynesians with recent type 2 diabetes.
  • This early renal abnormality, along with increased albuminuria, warrants further investigation.
  • Prospective studies are needed to link hyperfiltration to the development of overt nephropathy.