Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleep problems in multiple sclerosis

N Tachibana1, R S Howard, N P Hirsch

  • 1Harris Unit, National Hospital for Neurology and Neurosugery, London, UK.

European Neurology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum: There is inadequate evidence to support the division of the genus Borrelia.

International journal of systematic and evolutionary microbiology·2017
Same author

There is inadequate evidence to support the division of the genus Borrelia.

International journal of systematic and evolutionary microbiology·2016
Same author

Borrelia miyamotoi infection in nature and in humans.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015
Same author

Validation of a technique using microbubbles and contrast enhanced ultrasound (CEUS) to biopsy sentinel lymph nodes (SLN) in pre-operative breast cancer patients with a normal grey-scale axillary ultrasound.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2013
Same author

Primary thyroid-like follicular renal cell carcinoma: an emerging entity.

Case reports in pathology·2013
Same author

Frequency of electrocardiogram testing among HIV-infected patients at risk for medication-induced QTc prolongation.

HIV medicine·2013
Same journal

Combined Olfactory Testing and Substantia Nigra Hyperechogenicity for Diagnostic Differentiation of Parkinson's Disease.

European neurology·2026
Same journal

The Role of Stroke Severity in the Association between Hypoperfusion Intensity Ratio and Futile Reperfusion after Endovascular Treatment.

European neurology·2026
Same journal

The Parkinsonism of Salvador Dalí.

European neurology·2026
Same journal

Disorders of Arousal and Sleep-Related Hypermotor Epilepsy in Adults: A Challenging but Necessary and Critical Distinctive Diagnosis.

European neurology·2026
Same journal

Sex-Specific Phenotypic Characteristics in Obstructive Sleep Apnea: A Comprehensive Analysis of Anthropometric, Hematological, and Metabolic Profiles Stratified by Disease Severity.

European neurology·2026
Same journal

Historical and Clinical Analysis of a Case of Progressive Muscular Atrophy (1853-1871).

European neurology·2026
See all related articles

Sleep disturbances are common in multiple sclerosis (MS), often caused by spasms or nocturia. Sleep apnoea is a less common but significant cause of nocturnal respiratory issues in MS patients.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Medical Research

Background:

  • Sleep-related disorders are frequently observed in patients with multiple sclerosis (MS).
  • These disturbances can significantly impact patient quality of life and disease management.
  • The underlying causes and prevalence require further investigation.

Purpose of the Study:

  • To clinically evaluate sleep-related disorders in a cohort of multiple sclerosis patients.
  • To investigate the association between sleep disturbances and nocturnal oxygen desaturation.
  • To explore potential correlations between brain stem lesions and sleep-related respiratory issues.

Main Methods:

  • Clinical evaluation of 28 consecutive multiple sclerosis patients (12 males, 16 females) with varying disability scores (EDSS 1.5-8.5).

Related Experiment Videos

  • Patient-reported sleep problems including insomnia, leg spasms, snoring, and nocturia.
  • All-night oximetry to assess oxygen saturation (SaO2) dips, followed by polysomnography in select cases.
  • MRI analysis of brain stem regions.

    • Main Results:

    • 54% of patients (15/28) reported sleep problems, commonly leg spasms/discomfort and insomnia.
    • Three patients exhibited significant nocturnal oxygen desaturation (> 5 dips of > 4% SaO2/h).
    • Polysomnography confirmed sleep apnoea in 2 of these 3 patients. MRI revealed brain stem abnormalities in 20/22 patients, with no clear correlation to nocturnal desaturation.

    Conclusions:

    • Sleep disturbance is a common and often under-recognized issue in multiple sclerosis.
    • While typically linked to spasms, pain, or nocturia, sleep apnoea can cause nocturnal respiratory insufficiency.
    • Brain stem lesions are prevalent in MS but did not directly correlate with observed sleep apnoea in this study.