The effects of non-nutritional factors on growth in cerebral palsy

R D Stevenson1, C D Roberts, L Vogtle

  • 1Department of Pediatrics, University of Virginia School of Medicine.

Insights

Non-nutritional factors significantly impact growth in children with cerebral palsy (CP). Even without malnutrition, affected limbs in children with CP show smaller measurements compared to unaffected limbs.

Area of Science:

  • Pediatrics
  • Neurology
  • Human Growth and Development

Background:

  • Cerebral palsy (CP) is a complex neurological disorder affecting movement and posture.
  • Growth disturbances are common in children with CP, often attributed to nutritional deficits.
  • The independent role of non-nutritional factors in CP-related growth alterations requires further investigation.

Purpose of the Study:

  • To isolate and evaluate the impact of non-nutritional factors on the anthropometric measurements of children with hemiplegic cerebral palsy.
  • To compare growth parameters between the affected and unaffected sides of the body in children with CP.

Main Methods:

  • Anthropometric measurements were taken on both affected and unaffected sides of 20 children with hemiplegic CP.
  • Participants had normal stature and triceps skinfold measurements, controlling for general malnutrition.
  • Sixteen distinct anthropometric measures, including breadth, length, circumference, and skinfold thickness, were analyzed.

Main Results:

  • Significant reductions in breadth, circumference, and length were observed on the affected side compared to the unaffected side.
  • Skinfold measurements showed a trend towards being larger on the affected side.
  • These findings indicate asymmetry in growth related to the hemiplegic condition.

Conclusions:

  • Non-nutritional factors, intrinsically linked to the severity of cerebral palsy, exert a significant influence on child growth.
  • Disease-related factors, rather than solely nutritional status, contribute to observed growth disparities in children with CP.
  • The study highlights the importance of considering disease-specific non-nutritional influences on growth in pediatric populations with CP.

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children from...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...