Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Synchronous colorectal carcinomas

T Kimura¹, H Iwagaki, S Fuchimoto

¹First Department of Surgery, Okayama University Medical School, Japan.

Hepato-Gastroenterology

|October 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Refractory response to growth factors impairs liver regeneration after hepatectomy in patients with viral hepatitis.

Hepato-gastroenterology·2009

Same author

Effects of adenosine on adhesion molecule expression and cytokine production in human PBMC depend on the receptor subtype activated.

British journal of pharmacology·2007

Same author

Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system.

The Journal of international medical research·2005

Same author

beta2-adrenergic receptor stimulation-induced immunosuppressive effects possibly through down-regulation of co-stimulatory molecules, ICAM-1, CD40 and CD14 on monocytes.

The Journal of international medical research·2004

Same author

Enhanced effects of combined bu-zhong-yi-qi-tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-alpha and interferon-gamma in human peripheral blood mononuclear cells.

The Journal of international medical research·2004

Same author

Intraportal donor bone marrow transplantation improves intestinal allograft survival in rats under FK506-based immunosuppression.

The Journal of international medical research·2003

Synchronous colorectal carcinomas occur in 5% of patients and are associated with younger age and poorer prognosis. Early detection requires thorough pre-operative examination and intra-operative colonoscopy when needed.

Area of Science:

Gastroenterology
Oncology
Surgical Pathology

Background:

Synchronous colorectal carcinomas present a clinical challenge.
Understanding their characteristics and risk factors is crucial for improved patient outcomes.

Purpose of the Study:

To investigate the incidence, characteristics, and prognostic implications of synchronous colorectal carcinomas.
To identify factors influencing detection and suggest strategies for improved diagnosis.

Main Methods:

Retrospective analysis of 358 patients undergoing colorectal carcinoma resection between 1978-1990.
Comparison of patients with single versus synchronous carcinomas.
Review of pre-operative diagnostic methods and reasons for missed synchronous lesions.

Related Experiment Videos

Main Results:

Synchronous colorectal carcinomas were found in 5.0% of patients.
Patients with synchronous lesions were younger and had a higher incidence of mucinous carcinoma and a family history of malignancy.
The distance between synchronous lesions was <10 cm in 69.6% of cases.
Pre-operative detection occurred in 14/18 patients, with missed lesions often due to examination limitations.
Prognosis was worse in the synchronous lesion group compared to the solitary lesion group.

Conclusions:

Synchronous colorectal carcinomas are associated with specific patient and tumor characteristics, potentially influenced by hereditary factors.
Improved pre-operative assessment and intra-operative colonoscopy are essential for detecting synchronous lesions.
Early detection and management are critical for improving the prognosis of patients with synchronous colorectal carcinomas.