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Terfenadine toxicosis in dogs
1Department of Clinical Studies, University of Pennsylvania, Philadelphia 19104-6010.
Journal of the American Veterinary Medical Association
|October 1, 1994
Summary
Terfenadine, an antihistamine, can cause toxicosis in animals even at low doses. Accidental exposure requires immediate treatment including induced emesis and activated charcoal for effective management.
Area of Science:
- Veterinary Toxicology
- Pharmacology
Background:
- Terfenadine is a widely used antihistamine with a reported safety profile in humans and animals.
- This study investigates terfenadine toxicosis, a condition resulting from overdose or adverse reactions to the drug.
Observation:
- An index case of terfenadine toxicosis is detailed.
- Several additional cases reported to the National Animal Poison Control Center between 1987 and 1992 are analyzed.
- Adverse effects were observed at dosages as low as 6.6 mg/kg body weight.
Findings:
- Terfenadine toxicosis can occur at relatively low dosages.
- The National Animal Poison Control Center documented multiple instances of terfenadine-related adverse events.
Implications:
- Veterinarians and pet owners should be aware of the potential for terfenadine toxicity.
- Prompt treatment protocols involving emesis and activated charcoal are crucial for managing accidental terfenadine exposure.
- This highlights the importance of careful dosage monitoring for antihistamines in veterinary medicine.