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Noise-induced elevations of plasma endothelin (ET-3)
W S Quirk1, J K Coleman, J M Hanesworth
1Department of Otolaryngology, Wayne State University Detroit, MI 48201.
Hearing Research
|October 1, 1994
Summary
Prolonged noise exposure significantly elevates plasma endothelin-3 levels in rats, suggesting endothelin mediates noise-induced hemodynamic changes and vascular issues. Brief noise exposure did not alter these peptide levels.
Area of Science:
- Physiology
- Toxicology
- Cardiovascular Research
Background:
- Endothelins (ETs) are peptides crucial for hemodynamic homeostasis.
- Elevated circulating ETs are linked to stress conditions and vascular diseases.
Purpose of the Study:
- To investigate if plasma endothelin concentrations increase after noise exposure.
- To determine the relationship between noise duration and endothelin levels.
Main Methods:
- Radioimmunoassay (RIA) was used to measure plasma endothelin levels.
- Rats were exposed to brief (30 min) or prolonged (90 min, 72 h) 100 dB SPL broad-band noise.
Main Results:
- No significant change in plasma endothelin was observed after brief noise exposure.
- Statistically significant elevations in plasma endothelin-3 (ET-3) were detected following prolonged noise exposure.
Conclusions:
- Prolonged noise exposure, but not brief exposure, increases plasma endothelin-3.
- Endothelin may mediate hemodynamic alterations and vascular pathologies associated with prolonged noise exposure.