Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methadone withdrawal psychosis

I Levinson1, I I Galynker, R N Rosenthal

  • 1Beth Israel Medical Center, Department of Psychiatry, New York, NY 10003.

The Journal of Clinical Psychiatry
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supportive therapy as the treatment model of choice.

The Journal of psychotherapy practice and research·2012
Same author

Clinically meaningful improvement on the quality of erection questionnaire in men with erectile dysfunction.

International journal of impotence research·2009
Same author

Integrating services for schizophrenia and substance abuse.

The Psychiatric quarterly·2001
Same author

Pilot study of bright-light therapy reflected toward the eyes for the pruritus of chronic liver disease.

The American journal of gastroenterology·2001
Same author

Adding group psychotherapy to medication treatment in dysthymia: a randomized prospective pilot study.

The Journal of psychotherapy practice and research·2001
Same author

Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.

The Mount Sinai journal of medicine, New York·2000

Opioid taper, particularly with methadone, may trigger new-onset psychosis in susceptible individuals. This risk is heightened in those with prior central nervous system conditions, necessitating clinical awareness during withdrawal management.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Methadone, a mu-opioid receptor agonist, is standard for opioid dependence treatment.
  • While methadone withdrawal is documented, psychosis is not a typical symptom.

Observation:

  • New-onset psychosis was observed in a patient undergoing methadone taper.
  • A chart review identified three additional patients with similar presentations.

Findings:

  • Patients met criteria for opioid dependence; some had prior psychiatric history.
  • Psychosis resolved spontaneously in one case, required neuroleptics in others, and one needed methadone resumption.
  • None experienced typical methadone withdrawal symptoms.

Implications:

Related Experiment Videos

  • Opioid tapering may precipitate psychosis, especially in patients with pre-existing CNS disorders.
  • Clinicians must monitor for psychosis during opioid withdrawal.
  • Further research is needed to explore the link between opioid agonists and dopaminergic neurotransmission in psychosis.