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Related Experiment Videos

trk-immunoreactivity in the monkey central nervous system: forebrain

J H Kordower1, E Y Chen, J R Sladek

  • 1Department of Neurological Sciences, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.

The Journal of Comparative Neurology
|November 1, 1994
PubMed
Summary

This study maps tropomycin-related kinase (trk) receptor distribution in nonhuman primate brains, finding trk in basal forebrain neurons and suggesting its role in neurotrophin signaling across the lifespan.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Receptor Signaling

Background:

  • Neurotrophins, like nerve growth factor (NGF), are crucial for neuronal survival and function.
  • These neurotrophins exert their effects via high-affinity tropomycin-related kinase (trk) receptors.
  • Understanding trk receptor distribution is key to deciphering neurotrophin-mediated pathways.

Purpose of the Study:

  • To map the distribution of trk-immunoreactive neurons in the nonhuman primate brain.
  • To investigate the colocalization of trk receptors with the p75 neurotrophin receptor in the basal forebrain.
  • To assess the expression pattern of trk in aged primates.

Main Methods:

  • Utilized a polyclonal antibody to detect trk-immunoreactive neurons.
  • Employed colocalization studies with the p75 neurotrophin receptor.

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  • Examined brain tissue from young adult and aged cebus and rhesus monkeys.

    • Main Results:

    • trk-immunoreactive neurons were identified in all basal forebrain subdivisions in both young and aged monkeys.
    • 66-76% of trk-positive basal forebrain neurons also expressed the p75 neurotrophin receptor.
    • trk expression was observed in the striatum, hippocampus, and hypothalamus, suggesting broad neuronal expression.

    Conclusions:

    • Both cholinergic and potentially noncholinergic neurons express trk receptors in the primate forebrain.
    • trk receptor expression is largely maintained throughout the organism's lifespan.
    • These findings highlight the widespread role of trk receptors in neurotrophin signaling in the primate brain.