Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutaraldehyde: current status and uses

A D Russell1

  • 1Welsh School of Pharmacy, University of Wales College of Cardiff.

Infection Control and Hospital Epidemiology
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MiniBooNE and MicroBooNE Combined Fit to a 3+1 Sterile Neutrino Scenario.

Physical review letters·2022
Same author

Mupirocin, fusidic acid and bacitracin: activity, action and clinical uses of three topical antibiotics.

Veterinary dermatology·2021
Same author

Significant Excess of Electronlike Events in the MiniBooNE Short-Baseline Neutrino Experiment.

Physical review letters·2018
Same author

First Measurement of Monoenergetic Muon Neutrino Charged Current Interactions.

Physical review letters·2018
Same author

Biocides: mechanisms of action and microbial resistance.

World journal of microbiology & biotechnology·2014
Same author

Improved search for ν¯(μ)→ν¯(e) oscillations in the MiniBooNE experiment.

Physical review letters·2013
Same journal

Integrating patient in-hospital transfer patterns into automated outbreak detection systems: a single-center retrospective study.

Infection control and hospital epidemiology·2026
Same journal

Colonization with multidrug-resistant organisms (MDROs) including <i>Candidozyma auris</i> among residents in ventilator-designated versus non-ventilator-designated beds at skilled nursing facilities (SNFs).

Infection control and hospital epidemiology·2026
Same journal

Exploring unconventional antimicrobial stewardship models: options beyond traditional prospective audit and feedback.

Infection control and hospital epidemiology·2026
Same journal

Rectal versus groin screening for multidrug-resistant organisms: pathogen-specific diagnostic yield in a tertiary-care hospital.

Infection control and hospital epidemiology·2026
Same journal

Comparing rapid molecular and culture methods for detecting fungal contamination in healthcare environments.

Infection control and hospital epidemiology·2026
Same journal

Prospective validation and implementation of a model to identify patients with carbapenem-resistant Enterobacterales (CRE) carriage on admission to acute care hospitals.

Infection control and hospital epidemiology·2026
See all related articles

Glutaraldehyde is a powerful disinfectant effective against bacteria, fungi, and viruses. Despite toxicity concerns for healthcare workers, it is essential for high-level disinfection in endoscopy.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Glutaraldehyde (pentanedial) is a dialdehyde known for its broad-spectrum antimicrobial properties.
  • Its mechanism of action involves interaction with amino groups in microbial proteins and enzymes.
  • Despite known toxicity, it is widely used in healthcare settings.

Purpose of the Study:

  • To elucidate the antimicrobial mechanisms of glutaraldehyde.
  • To highlight its significance in high-level disinfection, particularly in endoscopy.

Main Methods:

  • Literature review on glutaraldehyde's chemical properties and antimicrobial activity.
  • Analysis of its inactivation pathways against various microorganisms.
  • Discussion of its application and limitations in clinical settings.

Related Experiment Videos

Main Results:

  • Glutaraldehyde exhibits potent bactericidal, fungicidal, mycobactericidal, sporicidal, and virucidal activity.
  • The compound inactivates microorganisms through complex interactions beyond simple amino group binding.
  • Its efficacy makes it indispensable for high-level disinfection in endoscopy.

Conclusions:

  • Glutaraldehyde is a critical agent for high-level disinfection due to its broad-spectrum efficacy.
  • Understanding its inactivation mechanisms is key to optimizing its use.
  • Risk management strategies are necessary to mitigate occupational hazards for medical staff.