Adult respiratory distress in pregnancy: critical care issues

Adult respiratory distress syndrome (ARDS) is a complex disease process involving noncardiogenic pulmonary edema, central hypovolemia, widespread atelectasis, and, in the final stages, an inability to perfuse end organs. Uteroplacental perfusion is usually compromised in such situations, which may be catastrophic, depending on the amount of fetal oxygen reserve. ARDS is often preceded by sepsis and frequently ends in maternal death, despite aggressive intervention. Inflammatory responses, complement activation, and prostaglandins have been implicated as probable mediators of both sepsis and ARDS. Invasive hemodynamic monitoring and mechanical ventilation are usually warranted to provide detailed assessment and support. However, when a critical illness affects the family unit, emotional and spiritual issues must receive significant attention to provide holistic care.