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High CTG repeat number in nodular thyroid tissue from a myotonic dystrophy patient
C Daumerie1, N Lannoy, J P Squifflet
1Service d'Endocrinologie, Cliniques Universitaires St Luc, Brussels, Belgium.
Journal of Medical Genetics
|November 1, 1994
Abstract:
CTG triplet expansion was studied in lymphocytes and thyroid tissue in a patient with myotonic dystrophy (DM) and associated thyroid nodular disease. An approximately 7 fold larger amplification was found in abnormal thyroid tissue compared to lymphocytes, suggesting that anomalies in the putative DM kinase gene might contribute to thyroid dysfunction.