Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Subacute sclerosing panencephalitis in Delhi

S Khare¹, S Kumari, T Verghese

¹National Institute of Communicable Diseases, Delhi, India.

Journal of Tropical Pediatrics

|December 1, 1994

Summary

Subacute sclerosing panencephalitis (SSPE) is more common in males and linked to measles infection in unvaccinated children. Measles antibodies are significantly higher in SSPE patients

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a history-taking form for mesothelioma patients at risk of exposure to asbestos.

Public health action·2025

Same author

Relative potency of norepinephrine and mephentermine bolus for the treatment of spinal hypotension during elective caesarean delivery: a randomized, blinded up-down sequential allocation study.

International journal of obstetric anesthesia·2025

Same author

Time-series multi-omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation.

Plant biology (Stuttgart, Germany)·2025

Same author

Anaesthesia for caesarean delivery in women with class 3 obesity: a retrospective cohort study from the north-west of England (2022-2023).

International journal of obstetric anesthesia·2025

Same author

Nociceptor Neurons Facilitate Orthodontic Tooth Movement via Piezo2 in Mice.

Journal of dental research·2025

Same author

Prevalence of antihypertensive medication adherence and associated factors in India: A systematic review and meta-analysis.

Hipertension y riesgo vascular·2024

Area of Science:

Virology
Neurology
Epidemiology

Background:

Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological complication of measles virus infection.
It primarily affects children and young adults, leading to severe neurological deficits and often death.

Purpose of the Study:

To investigate the epidemiological and virological characteristics of SSPE cases in Delhi.
To analyze measles virus antibody titers in serum and cerebrospinal fluid (CSF) of SSPE patients.

Main Methods:

Retrospective analysis of 65 SSPE cases referred to the Virology Laboratory, National Institute of Communicable Diseases, Delhi (1989-1992).
Collection of demographic data, clinical history (including measles exposure and vaccination status), and serum/CSF samples.
Measurement of measles virus-specific antibodies using hemagglutination inhibition (HAI) assays.

Main Results:

SSPE cases (n=65) were predominantly male (6:1 ratio) and aged 2-24 years.
A history of measles infection was reported in most patients under 3 years; no SSPE patients had a history of measles vaccination.
Significantly elevated serum and CSF measles HAI antibody titers were observed in SSPE patients compared to controls.

Conclusions:

The study reinforces the association between measles virus infection and SSPE, particularly in unvaccinated individuals.
The findings highlight the importance of measles vaccination in preventing SSPE.
Elevated measles antibody titers in serum and CSF are indicative of SSPE.

Related Experiment Videos