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[Cholesterol ester transfer protein (CETP)]

N Nakaya1

  • 1Department of Medicine, Tokai University, Tokyo Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 1, 1994
PubMed
Summary

Cholesteryl ester transfer protein (CETP) moves lipids between lipoproteins, influencing cholesterol transport. High CETP activity promotes atherosclerosis, while low activity offers resistance.

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Area of Science:

  • Biochemistry
  • Lipid Metabolism
  • Cardiovascular Science

Context:

  • Cholesterol transport is crucial for preventing atherosclerosis.
  • Plasma cholesteryl ester transfer protein (CETP) is a key regulator in reverse cholesterol transport.
  • Understanding CETP's role is vital for developing therapies against cardiovascular diseases.

Purpose:

  • To review the molecular characteristics, lipid transfer mechanisms, synthesis, regulation, and consequences of CETP activity.
  • To elucidate the link between CETP function and lipoprotein abnormalities.
  • To explore the implications of CETP activity in atherosclerosis development.

Summary:

  • CETP mediates the transfer of cholesteryl esters from HDL to apo B-containing lipoproteins and triglycerides from VLDL/IDL to HDL.
  • This review details CETP's molecular properties, lipid transfer mechanisms, synthesis sites, and regulatory factors.
  • Lipoprotein abnormalities in CETP deficiency and the atherogenic potential of high CETP activity are discussed.

Impact:

  • High CETP activity is linked to atherogenic lipoprotein changes, promoting atherosclerosis.
  • Individuals and animals with low CETP activity exhibit resistance to atherosclerosis.
  • Findings underscore CETP as a potential therapeutic target for cardiovascular disease prevention.

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