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Aconite induced myelo-optic neuropathy in a rabbit model
1Department of Biochemistry, Hyosung University College of Pharmacy, Korea.
Korean Journal of Ophthalmology : KJO
|December 1, 1994
Summary
Aconite poisoning in rabbits damages the myelin sheath, causing visual pathway and nerve damage. This suggests aconite may primarily cause myelo-optic neuropathy, affecting vision.
Area of Science:
- Toxicology
- Neuroscience
- Ophthalmology
Background:
- Aconite is a traditional remedy widely used in East Asia.
- Clinical visual disturbances from aconite are known, but its pathology is poorly understood.
Purpose of the Study:
- To investigate the toxic effects of Tinctura aconiti on the rabbit visual system.
- To elucidate the pathological mechanisms underlying aconite-induced visual disturbances.
Main Methods:
- Rabbits received intraperitoneal injections of Tinctura aconiti.
- Visual evoked potentials (VEPs) were recorded to assess visual pathway function.
- Histopathological examination of the visual pathway, spinal cord, and peripheral nerves was performed.
Main Results:
- Aconite administration caused delays in the onset and peak latency of VEPs.
- Histopathology revealed myelin sheath damage in the visual pathway, spinal cord, and peripheral nerves.
Conclusions:
- Aconite exhibits toxic effects on the rabbit visual system.
- Findings suggest aconite may primarily induce myelo-optic neuropathy.