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Copy-dependent and correct developmental expression of the human neurofilament heavy gene in transgenic mice
1Centre for Research in Neurosciences, McGill University, Montreal General Hospital Research Institute, Que., Canada.
Brain Research. Molecular Brain Research
|October 1, 1994
Abstract:
We recently produced four lines of transgenic mice bearing a 34 kb DNA fragment that includes the human gene coding for the neurofilament heavy (NF-H) chain. Analysis of the NF-H transgenics revealed an increase in human NF-H mRNA and protein that parallels the increase in gene copy number, providing the first example of a transgene with copy-dependent expression in neurons. In addition, expression of the human NF-H transgene is induced post-natally following a developmental pattern similar to the endogenous mouse NF-H gene.