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Updated: Aug 12, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
[Contribution and role of polymorphonuclear leucocytes in inflammatory reactions of asbestosis]
E Lewczuk1, H Owczarek, G Staniszewska
1Kliniki Chorób Wewnetrznych i Zawodowych, Akademii Medycznej we Wrocławiu.
Abstract:
The mechanism of lung fibrosis after asbestos exposure is unknown. Observations suggest that neutrophils may play a role in the development of the lung injury in asbestosis. They are attracted to the lungs by macrophages mediators and there they phagocyte asbestos fibres. A cytotoxic effect of asbestos exerted on polymorphonuclear leucocytes releases proteolytic enzymes such as collagenase and elastase. Besides, asbestos produces highly reactive oxidants in neutrophils responsible for an additional damage of tissues. However, the role of polymorphonuclear leucocytes in pathogenesis of asbestosis still remains controversial.
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