Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scatter factor/hepatocyte growth factor is essential for liver development

C Schmidt1, F Bladt, S Goedecke

  • 1Max-Delbrück Laboratorium in der Max-Planck-Gesellschaft, Köln, Germany.

Nature
|February 23, 1995
PubMed
Summary

Scatter factor/hepatocyte growth factor (SF/HGF) is vital for embryonic development. Mice lacking SF/HGF die in utero due to impaired liver and placenta development, highlighting its essential role in organogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomics boosts mouse molecular genetics.

Trends in genetics : TIG·2001
Same author

Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·2001
Same author

Mr. Bush charts his energy future.

Environmental science & technology·2001
Same author

Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death.

Pancreas·2001
Same author

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

The Journal of biological chemistry·2001
Same author

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.

Neuron·2001

Area of Science:

  • Developmental biology
  • Cell signaling
  • Molecular genetics

Background:

  • Polypeptide growth factors regulate cell growth and differentiation.
  • Scatter factor/hepatocyte growth factor (SF/HGF) is a key growth factor.
  • SF/HGF signaling involves the c-Met tyrosine kinase receptor.

Purpose of the Study:

  • To investigate the in vivo role of SF/HGF in embryonic development.
  • To determine the consequences of SF/HGF deficiency during development.

Main Methods:

  • Generation of SF/HGF knockout mice.
  • Analysis of embryonic development and organ morphology in mutant mice.

Main Results:

  • SF/HGF-deficient mice exhibit embryonic lethality, dying in utero.

Related Experiment Videos

  • Mutant embryos show reduced embryonic liver size and parenchymal cell loss.
  • Placental development, including trophoblast cells, is impaired in SF/HGF-deficient embryos.

    • Conclusions:

    • SF/HGF is essential for embryonic development and survival.
    • SF/HGF plays a critical role in the development of the embryonic liver and placenta.
    • SF/HGF is indispensable for the development of multiple epithelial organs.