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Processing considerations for an EC latex coating system: influence of curing time and temperature
D Hutchings1, B Kuzmak, A Sakr
1Department of Pharmaceutics and Drug Delivery Systems, College of Pharmacy, University of Cincinnati, Ohio 45267.
Pharmaceutical Research
|October 1, 1994
Summary
Curing temperature significantly impacts ethylcellulose coating drug release, with plasticizer choice altering the effect of rigorous conditions on release rates. Higher temperatures generally accelerated drug release.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Ethylcellulose latex dispersions are widely used for controlled drug release coatings.
- Understanding the impact of processing parameters like curing on coating performance is crucial for formulation development.
Purpose of the Study:
- To investigate the influence of curing time and temperature on the drug release characteristics of ethylcellulose coatings.
- To evaluate the role of different plasticizers in modulating the effect of curing conditions.
Main Methods:
- Response surface methodology was employed to analyze the effects of curing time (30-300 min) and temperature (45-75°C).
- Dissolution profiles were analyzed to derive parameters representing maximum drug release (A), release rate (kappa), and inflection point (gamma).
- Two plasticizers, dibutyl sebacate and tributyl citrate, were incorporated into the coating formulations.
Main Results:
- Curing temperature exerted a more significant influence on drug release than curing time.
- The plasticizer type critically altered the response surface: dibutyl sebacate led to faster release under harsher conditions, while tributyl citrate resulted in slower release.
- Higher curing temperatures and longer curing times generally increased drug release with dibutyl sebacate.
Conclusions:
- Curing conditions and plasticizer selection are critical factors in controlling ethylcellulose coating drug release profiles.
- The interaction between plasticizer type and curing parameters dictates the final drug release behavior, offering opportunities for tailored formulation design.