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Interferon response in pigs: molecular and biological aspects
C La Bonnardière1, F Lefèvre, B Charley
1I.N.R.A., Jouy-en-Josas, France.
Veterinary Immunology and Immunopathology
|October 1, 1994
Summary
Porcine interferons (IFN) play roles in host defense and pregnancy. Research shows pig embryos secrete unique interferons, including IFN gamma from the trophoblast, crucial for early gestation.
Area of Science:
- Immunology
- Reproductive Biology
- Veterinary Science
Background:
- Porcine interferons (IFN) are critical for immune responses and reproductive processes.
- Understanding porcine IFN subtypes and their functions is essential for animal health and breeding.
Purpose of the Study:
- To review the current knowledge on porcine interferons (IFN).
- To discuss the roles of IFNs in host responses to infections and in pregnancy.
Main Methods:
- Literature compilation of porcine IFN genes and recombinant proteins.
- Review of studies on IFN production in virus-infected pigs.
- Analysis of embryonic IFN secretion during implantation.
Main Results:
- Identified three type I IFN subfamilies (IFN alpha, beta, omega) and one type II IFN (IFN gamma) in pigs.
- Demonstrated IFN secretion by pig embryos, including high levels of IFN gamma from the trophoblast.
- Revealed a novel trophoblastic type I IFN with distinct size and sequence.
Conclusions:
- Porcine embryonic IFNs, particularly trophoblastic ones, likely play significant roles in early gestation.
- Further research is needed to elucidate the specific functions of these embryonic IFNs.