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Related Experiment Videos

Infection markers during labor at term

L Keski-Nisula1, S Suonio, M Makkonen

  • 1Department of Obstetrics and Gynaecology, University Hospital of Kuopio, Finland.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1995
PubMed
Summary

This study found that while C-reactive protein (CRP) and white blood cell (WBC) counts increase during labor, they are unreliable for diagnosing intra-amniotic infection. Amniotic fluid tests also showed limited accuracy in detecting infection during vaginal delivery.

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Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Infectious Diseases

Background:

  • Intra-amniotic infection (IAI) is a significant complication during labor.
  • Accurate and timely diagnosis of IAI is crucial for effective management.
  • Biomarkers such as C-reactive protein (CRP) and white blood cell (WBC) count are often used to assess infection.

Purpose of the Study:

  • To prospectively evaluate the diagnostic utility of serum CRP, serum WBC, amniotic fluid WBC, and leukocyte esterase (LE) activity for intra-amniotic infection.
  • To compare these markers with amniotic fluid bacterial cultures in women in labor.

Main Methods:

  • Serial measurements of serum CRP and WBC, and amniotic fluid WBC and LE activity were performed in 30 women in labor.
  • Amniotic fluid samples were collected via an intrauterine catheter.

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  • LE activity was assessed using dipstick and photometric methods.
  • Results were retrospectively compared with amniotic fluid bacterial cultures.

    • Main Results:

    • Serum CRP and WBC levels, as well as amniotic fluid WBC and LE activity, increased significantly during labor.
    • Elevated CRP and WBC levels correlated with longer labor duration.
    • No clear association was found between amniotic fluid bacterial colonization and LE activity or WBC count by Gram stain.

    Conclusions:

    • The evaluated tests, including serum CRP, WBC, and amniotic fluid LE activity, are not reliable for diagnosing intra-amniotic infection during labor and vaginal delivery.
    • Further research is needed to identify more accurate diagnostic methods for IAI.