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Acute respiratory failure and intravascular coagulation
Surgery, Gynecology & Obstetrics
|October 1, 1976
Summary
This study found no direct link between acute respiratory failure and disseminated intravascular coagulation in severe cases. While some coagulation markers changed, full disseminated intravascular coagulation did not develop, suggesting no cause-and-effect relationship.
Area of Science:
- Critical Care Medicine
- Hematology
- Pulmonology
Background:
- Severe acute respiratory failure (ARF) presents with significant physiological derangements.
- The potential link between ARF and disseminated intravascular coagulation (DIC) requires investigation.
Purpose of the Study:
- To examine the association between severe acute respiratory failure and disseminated intravascular coagulation.
- To assess coagulation parameters in patients with severe ARF.
Main Methods:
- Studied eight patients with severe ARF requiring mechanical ventilation and PEEP.
- Monitored platelet count, fibrin split products, fibrinogen, PT, and aPTT.
- Assessed coagulation status during peak respiratory illness.
Main Results:
- No patient developed DIC during the study period.
- Platelet concentration decreased significantly (p<0.001) and fibrin split products increased (p<0.05) by day four.
- Other coagulation parameters remained largely unchanged.
Conclusions:
- Severe acute respiratory failure did not lead to disseminated intravascular coagulation in this patient cohort.
- Observed coagulation changes do not suggest a direct cause-and-effect relationship between ARF and DIC.